Huntington’s chorea or disease is a progressive, autosomal, fatal, and inherited disorder of the central nervous system chararacterized by widespread degenerative changes of the cerebral cortex, basal ganglia and other brain regions and the development of prominent chorea and dementia. Huntington’s disease is an inherited disease of the central nervous system that usually has its onset between 30 and 50 years of age. The patient has progressive dementia involuntary movements of chorea. A patient with Huntington’s disease may present with neurological or psychiatric symptoms or both. Huntington’s disease caused by the expansion of CAG (cytosine-adenine-guanine) in HD gene resulting in mutant form of the protein huntingtin. Symptomatic treatment of Huntington’s disease involves use of Dopamine antagonists, presynaptic dopamine depletes, Antidepressants, Tranquillizers, Anxiolytic Benzodiazepines, Anticonvulsants and Antibiotics. Several medications including Baclofen, Idebenone and vitamin E have studied in clinical trials with limited samples. In the present discussion, we have concentrated on introduction, history, epidemiology, inheridity, neurologic & hypothalamic-endocrine aspects, sign & symptoms, diagnosis, symptomatic approaches and other possible therapies involved in the management of Huntington’s disease. The aim of present discussion is to provide in depth knowledge about HD disease and symptomatic treatment and other therapies involved in the management of Huntington’s disease. This reviews current therapeutic agents for treatment of the symptoms of Huntington’s disease.
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